منابع مشابه
Synergy between sulphonamide and trimethoprim in the presence of pus.
Synergy between sulphadiazine and trimethoprim against Escherichia coli has been demonstrated in culture media not containing lysed horse blood despite the presence of pus or a pus extract which inhibited the action of each drug separately. Synergy may therefore be important where pus is present in vivo.
متن کاملTherapeutic trial of trimethoprim as a potentiator of sulphonamides in gonorrhoea.
Trimethoprim (2,4,diamino-5-(3',4',5'-trimethoxybenzyl) pyrimidine) is an antifolic acid agent developed by workers at the Wellcome Research Laboratories (Hitchings, Elion, Falco, Russell, Sherwood, and Vanderwerff, 1950a, b). It was found to inhibit the enzyme dihydrofolic acid reductase in bacteria with little or none of this activity against the corresponding enzymes of mammalian species (Hi...
متن کاملHaematological changes in a patient on long-term treatment with a trimethoprim-sulphonamide combination.
TRIMETHOPRIM (TMP) is an antibacterial chemotherapeutic agent of great interest as it is the first folic acid antagonist to be effective in the treatment for human bacterial infections. It is related to the antimalarial drug pyrimethamine, and similarly inhibits the enzyme dihydrofolate reductase. This enzyme is essential for the incorporation offolate into cell metabolism (see Fig. 1). There a...
متن کاملAnisaldehyde, a melanogenesis potentiator.
Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations s...
متن کاملSulphonamide Anuria
A Mohammedan male, aged 15 years, was admitted to the surgical ward of this hospital on 29th December, 1945, for osteomyelitis of the right leg. A course of sulphonamide two tablets thrice daily was prescribed and the leg was operated on. Ten days later he showed signs of pain and fullness over the back and loin, and there was complete anuria. Sulphonamide was at once stopped, and alkaline mixt...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1968
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1968.tb00475.x